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New acylcarnitine ratio as a reliable indicator of long-chain 3-Hydroxyacyl-CoA dehydrogenase deficiency

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Pyridoxine needs are elevated during pregnancy

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In this context, an intrinsic defect has been hypothesized in the acylated ghrelin/unacylated ghrelin ratio in circulation, resulting in a relative acylated ghrelin deficit in PWS infants and a subsequent excess in later life that correlates with the switch in feeding behavior